Optimized expression of hpv 58 l1 in yeast

Details Optimized expression of hpv 58 l1 in yeast Optimized expression of hpv 58 l1 in yeast

C - Chemistry, Metallurgy

07

K

C07K 14/025 (2006.01)

Patent

CA 2543928

Synthetic DNA molecules encoding the HPV58 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV58 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV58 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV58 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity and are also useful for treatment of existing HPV infections.

L'invention concerne des molécules d'ADN codant la protéine de HPV58 L1. Elle concerne, plus particulièrement, des polynucléotides codant la protéine de HPV58 L1, lesdits polynucléotides présentant une optimisation au niveau du codon dans le but d'une expression à niveau élevé dans une cellule de levure. On peut utiliser ces molécules synthétiques afin de produire des particules semblables au virus HPV58 (VLP), ainsi que des vaccins et des compositions pharmaceutiques contenant ces VLP de HPV58. Ces vaccins exercent un effet immunoprophylactique efficace contre l'infection par papillomavirus par l'intermédiaire d'un anticorps de neutralisation et d'une immunité véhiculée par les cellules et ils sont également utiles pour traiter des infections existantes par HPV.

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