Optimized host cells for protein production

Details Optimized host cells for protein production Optimized host cells for protein production

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2670514

The present invention relates to methods for isolating cells that express increased levels of an RNA or protein of interest, wherein the cells exhibit altered growth profiles, such as cells with increased or decreased rates of proliferation, increased or decreased rates of apoptosis, or cells with a biphasic growth profile.

La présente invention concerne des procédés destinés à isoler des cellules qui expriment des niveaux supérieurs d'un ARN ou d'une protéine d'intérêt. Dans la présente invention, les cellules présentent des profils de croissance modifiés, tels que des cellules présentant une vitesse de prolifération augmentée ou diminuée, un taux d'apoptose augmenté ou diminué, ou des cellules présentant un profil de croissance biphasique.

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