Optimized nucleic acid sequences for the expression of vb4-845

Details Optimized nucleic acid sequences for the expression of vb4-845 Optimized nucleic acid sequences for the expression of vb4-845

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) C07K 7/06 (2006.01) C07K 14/00 (2006.01) C07K 14/21 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 15/11 (2006.01) C12N 15/13 (2006.01) C12N 15/67 (2006.01) C12N 15/70 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2700815

An optimized nucleic acid sequence encoding the immunoconjugate VB4-845 is disclosed. Modifications to the original VB4-845 nucleic acid sequence include optimization of the sequences encoding the V H region, V L region, linkers and pseudomonas exotoxin A. The modifications improved the yield of VB4-845 in an Escherichia coli expression system

L'invention concerne des séquences d'acides nucléiques optimisées pour une meilleure expression des protéines recombinantes.

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