Optimized probe selection method

Details Optimized probe selection method Optimized probe selection method

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/00 (2006.01) C40B 30/04 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2600199

The present invention provides methods for optimizing oligonucleotide hybridization probes for use in basic and clinical research. Specifically, the invention involves hybridizing serially diluted genomic sample to the oligonucleotide probes on the array, such that a signal intensity is produced for each of the probes; computationally identifying optimized probes which exhibit signal intensities that correspond to the serial dilutions of genomic sample and are reproducibly strong relative to non-optimized probes.

La présente invention se rapporte à des procédés permettant d'optimiser des sondes d'hybridation oligonucléotidiques, qui sont destinés à la recherche fondamentale et clinique. Précisément, l'invention consiste à hybrider un échantillon génomique dilué en série avec les sondes oligonucléotidiques sur le réseau, de façon qu'une intensité de signal soit produite pour chacune des sondes, et à identifier par calcul des sondes optimisées, qui présentent des intensités de signal correspondant aux dilutions en série de l'échantillon génomique, et sont résistantes et reproductibles par rapport aux sondes non optimisées.

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