Optimized use of 6-mercaptopurine drug in the treatment of...

Details Optimized use of 6-mercaptopurine drug in the treatment of... Optimized use of 6-mercaptopurine drug in the treatment of...

G - Physics

01

N

G01N 33/48 (2006.01) A61K 31/52 (2006.01) A61P 1/04 (2006.01) G01N 30/02 (2006.01)

Patent

CA 2345100

The present invention provides a method of optimizing therapeutic efficacy and reducing toxicity associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease. The method of the invention includes the step of determining the level of one or more 6-mercaptopurine metabolites in the patient having an immune-mediated gastrointestinal disorder.

Procédé permettant d'optimiser l'efficacité thérapeutique et de réduire la toxicité associée au traitement médicamenteux à base de 6-mercaptopurine d'une maladie gastro-intestinale à médiation immune, telle que la maladie intestinale inflammatoire. Le procédé selon la présente invention consiste à déterminer le taux d'un ou plusieurs métabolites de 6-mercaptopurine chez le patient souffrant d'une maladie gastro-intestinale à médiation immune.

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