Oral absorption enhancement of carboxylic acid...

Details Oral absorption enhancement of carboxylic acid... Oral absorption enhancement of carboxylic acid...

C - Chemistry, Metallurgy

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C07D 317/30 (2006.01) C07D 317/40 (2006.01) C07D 405/14 (2006.01) C07D 499/88 (2006.01) C07D 501/20 (2006.01) C07F 7/08 (2006.01) C07F 9/655 (2006.01)

Patent

CA 1202020

TITLE OF THE INVENTION ORAL ABSORPTION ENHANCEMENT OF CARBOXYLIC ACID PHARMACEUTICALS USING (5-ALKYL-2-OXO-1,3-DIOXOLEN- 4-YL)METHYL ESTER GROUP ABSTRACT OF THE INVENTION The (5-R-2-oxo-1,3-dioxolen-4-yl)methyl moiety: Image I wherein R is loweralkyl of 1-6 carbon atoms, especially methyl or t-butyl; when utilized as an ester on a phar- maceutical having a carboxylic acid functionality, enhances oral absorption of the pharmaceutical. This effect is applicable to a broad range of pharmaceu- tically active substances, including antibiotics, and antihypertensives as well as other classes of therapeutic agents.

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