A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/485 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61P 25/04 (2006.01)
Patent
CA 2452874
In a method of treating pain, a patient is administered a pharmaceutical composition of 6-hydroxy oxymorphone in an amount sufficient to induce analgesia. In one embodiment, the pharmaceutical composition is administered orally. Any known or later developed method of oral delivery may be used. To achieve the desired analgesic effect, blood plasma levels of 6-hydroxy oxymorphone are raised to at least approximately 0.2 ng/mL. Most preferably blood plasma levels of 6-hydroxy oxymorphone range at least 0.3 ng/mL during treatment. Administration of compositions containing 6-hydroxy oxymorphone, and one or more carriers, diluents, and excipients in an amount sufficient to induce analgesia is also contemplated.
L'invention concerne une méthode de traitement de la douleur, consistant à administrer une composition pharmaceutique contenant 6-hydroxy oxymorphone dans une quantité suffisante pour induire une analgésie. Dans un mode de réalisation, on administre par voie buccale ladite composition pharmaceutique. On peut utiliser n'importe quelle méthode connue ou récente d'administration orale. Pour atteindre l'effet analgésique souhaité, les niveaux du plasma sanguin en 6-hydroxy oxymorphone sont élevés à au moins environ 0,2 ng/mL. De préférence, les niveaux du plasma en 6-hydroxy oxymorphone se situent à au moins 0,3 ng/mL pendant le traitement. Cette invention a aussi trait à l'administration de compositions renfermant 6-hydroxy oxymorphone et au moins un porteur, un diluant et un excipient dans une quantité suffisante pour induire l'analgésie.
Kao Huai-Hung
Lee David
Mccall Troy
Smith-Carliss Richard
Endo Pharmaceuticals Inc.
Goudreau Gage Dubuc
LandOfFree
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