Oral administration of pneumococcal antigens

Details Oral administration of pneumococcal antigens Oral administration of pneumococcal antigens

A - Human Necessities

61

K

A61K 39/09 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2222965

Oral or peroral administration, including intragastrically, of killed whole pneumococci, lysate of pneumococci and isolated and purified PspA, as well as immunogenic fragments thereof, particularly when administered with an adjuvant such as cholera toxin provides protection in a host, animal or human, against pneumococcal infection, including colonization, and systemic infection, such as sepsis. The ability to elicit protection against pneumococcal colonization in a host prevents carriage among immunized individuals, wich can lead to elimination of disease from the population as a whole.

L'administration par voie orale ou perorale, y compris par voie intragastrique, de pneumocoques tués, de lysat de pneumocoques et de protéine A de la face membranaire du pneumocoque (PsaA) isolée et purifiée ainsi que de fragments immunogènes de celle-ci, notamment lorsqu'elle s'effectue en compagnie d'un adjuvant tel que la toxine cholérique, protège l'hôte, animal ou humain, contre l'infection pneumococcique, y compris une colonisation pneumococcique, et contre une infection généralisée telle que la septicémie. La possibilité d'obtenir une protection contre la colonisation pneumococcique chez un hôte évite tout hébergement par des individus immunisés, ce qui est susceptible de conduire à l'éradication de la maladie dans l'ensemble d'une population.

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