Oral capsule formulation with increased physical stability

Details Oral capsule formulation with increased physical stability Oral capsule formulation with increased physical stability

A - Human Necessities

61

K

A61K 9/48 (2006.01) A61K 47/12 (2006.01) A61K 47/14 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2466868

A formulation for a stabilized capsule for oral administration of a hydrophobic pharmaceutically active agent; comprising a non-aqueous solubilizer selected from 2-pyrrolidone, N-alkylpyrrolidones and combinations thereof; and a capsule stabilizing agent selected from mono-,di-and triglycerides, mono-and di-fatty esters of polyethylene glycol, fatty acids and combinations thereof wherein capsule integrity is maintained for at least 24 hours is disclosed.

L'invention concerne une formulation de gélule stabilisée permettant l'administration par voie orale d'un agent hydrophobe présentant une activité pharmaceutique. Cette formulation comprend un solubilisant non aqueux sélectionné parmi le 2-pyrrolidone, les N-alkylpyrrolidones et des combinaisons de ceux-ci, et un stabilisateur de gélule sélectionné parmi les mono, di et triglycérides, les mono ou diesters d'acides gras de polyéthylène glycol, les acides gras et une combinaison de ceux-ci, l'intégrité de la gélule étant préservée pendant au moins 24 heures.

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