Oral care compositions comprising increased bioavailable...

A - Human Necessities – 61 – K

Patent

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Details

A61K 8/41 (2006.01) A61Q 11/00 (2006.01)

Patent

CA 2554730

Disclosed are oral care compositions, including therapeutic rinses, especially mouthrinses and methods of use to provide significantly enhanced antimicrobial activity, thereby reducing oral bacteria and promoting overall oral health. The present compositions are formulated to deliver increased bioavailable levels of cationic antimicrobials, particularly quaternary ammonium compounds such as cetylpyridinium chloride (CPC) and are useful for preventing and treating diseases or conditions of the oral cavity including dental plaque, caries, gingivitis, periodontal disease and breath malodor. The present compositions are formulated to be essentially free of anionic, nonionic or amphoteric surfactants, which have been found to have a negative effect on bioavailability of the quaternary ammonium compounds and thus, their antimicrobial efficacy.

L'invention concerne des compositions de soin buccal comprenant des bains thérapeutiques, notamment des bains de bouche, ainsi que des méthodes d'utilisation, permettant de produire une activité antimicrobienne sensiblement accrue, réduisant ainsi les bactéries orales et favorisant la santé bucco-dentaire. Les compositions de l'invention sont préparées de manière qu'elles libèrent des taux biodisponibles d'agents antimicrobiens cationiques, notamment des composés d'ammonium quaternaire, tels que du chlorure de cétylpyridinium (CPC), et sont utiles pour la prévention et le traitement de maladies ou d'états de la cavité buccale, dont la plaque dentaire, les caries, la gingivite, la parodonthopathie et la mauvaise haleine. Ces compositions sont préparées de manière qu'elles soient sensiblement exemptes de tensioactifs anioniques, non-ioniques ou amphotères, lesquels se sont avérés avoir un effet négatif sur la biodisponibilité des composés d'ammonium quaternaires et ainsi, sur leur efficacité antimicrobienne.

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