Oral coated active drugs

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/55 (2006.01) A61K 9/28 (2006.01) A61K 9/30 (2006.01) A61K 9/48 (2006.01) A61K 9/56 (2006.01) A61K 31/216 (2006.01) A61K 31/221 (2006.01) A61K 31/42 (2006.01) A61K 31/5517 (2006.01)

Patent

CA 2251022

An oral drug dosage unit, for administration to a patient, having active drug, and an effective diameter and surface composition sufficient for the unit to be transported from the stomach into the duodenum following substantially complete emptying of chyme from the stomach into the intestine and prior to release of active drug from the unit, wherein the active drug has an absorption rate that is substantially affected by the coinciding presence of food in the stomach, the effective diameter of the unit prevents gastric emptying of the unit prior to gastric emptying of chyme, and the surface composition is an enteric coating which prevents release of the active drug in the stomach and allows release of the active drug in the intestine.

Dose unitaire de médicaments à administration par voie orale constituée d'un médicament actif présentant un diamètre efficace et d'une composition superficielle permettant le transport de cette dose de l'estomac au duodenum une fois que le chyme se trouve pratiquement entièrement déversé de l'estomac dans l'intestin et avant que le médicament actif ne soit libéré de la dose. Le médicament actif présente un rythme d'absorption qui est considérablement affecté par la présence concomitante d'aliments dans l'estomac. Le diamètre efficace de la dose empêche sa libération dans l'estomac avant le transfert du chyme gastrique, tandis que la composition superficielle est constituée d'un revêtement entérique empêchant la libération du médicament actif dans l'estomac mais permettant cette libération dans l'intestin.

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