Oral compositions

C - Chemistry – Metallurgy – 07 – F

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C07F 15/00 (2006.01) A61K 31/28 (2006.01)

Patent

CA 1259325

A B S T R A C T An orally-administrable pharmaceutical composition for the treatment of cancer comprising a coordination compound of platinum having a general. formula (A)(B)Pt(X)(Y)trans(Z)2 in which A and B are the same or different and are each selected from ammine and alkylamines or together represent a diaminocycloalkane, X and Y are the same or different and are selected from halide and pseudohalide or together represent cycloalkanedicarboxylate, with the provisos that when X and Y together represent cycloalkanedicarboxylate A and B do not represent ammine and/or alkylamine and when A and B together represent a diaminocyclohexane X and Y do not represent halide and/or pseudohalide, and the Z moieties are optional and are selected from halide and hydroxy, in association with a pharmaceutically-acceptable orally administrable carrier therefor.

465953

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