Oral compositions for the treatment of non-diabetic obese...

Details Oral compositions for the treatment of non-diabetic obese... Oral compositions for the treatment of non-diabetic obese...

A - Human Necessities

61

K

A61K 33/24 (2006.01)

Patent

CA 2447141

Oral compositions containing an effective amount of a tungsten compound (VI), preferably a tungstate salt, more preferably sodium tungstate (Na2WO4), are useful in controlling obesity/overweightness in non-diabetic mammals, including humans. The anti-obesity effect of sodium tungstate dihydrate in rats has been determined in a cafeteria-diet-induced obesity model. Said obese rats are good models of obese, non-diabetic mammals, including humans. The prophylactic, therapeutic and/or cosmetic treatment resulting from this invention is surprising. It provides advantages such as effectiveness, lack of toxicity and relatively low price in comparison with other treatments in prior art. Hence, the oral compositions according to the invention are useful for the treatment of obesity/overweightness in non-diabetic mammals, including humans.

L'invention concerne des compositions pharmaceutiques orales qui contiennent une quantité efficace d'un composé de tungstène (VI), de préférence d'un tungstate, idéalement de tungstate sodique (Na¿2?WO¿4?). Ces compositions sont utiles pour combattre l'obésité et l'excès de poids chez de mammifères non diabétiques, y compris des humains. L'effet anti-obésité du dihydrate de tungstate sodique a été déterminé sur des souris, dans un modèle d'obésité induite par la diète appelée "diète de cafétéria". Ces souris obèses constituent un bon modèle de mammifères obèses et non diabétiques, y compris des humains. Le traitement prophylactique, thérapeutique et/ou cosmétique issu de cette invention est surprenant et présente, sur les traitement existants, des avantages tels que l'efficacité, l'absence de toxicité et un prix relativement bas. Par conséquent, les compositions orales selon l'invention sont utiles pour le traitement de l'obésité et de l'excès de poids chez des mammifères non diabétiques, y compris des humains.

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