A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/403 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 31/138 (2006.01) A61P 9/12 (2006.01)
Patent
CA 2447005
The present invention relates to an oral controlled release pharmaceutical composition for once-a-day therapy for the treatment and prophylaxis of cardiac and circulatory diseases comprising carvedilol or its pharmaceutically acceptable salt or ester and release rate controlling excipients, wherein the said composition is adapted to release the carvedilol in a controlled manner so as to provide control over carvedilol plasma levels, such that the ratio of peak plasma levels to the plasma levels at 24 hours after administration, and the means residence time of carvedilol, are within a desirable range for said once-a-day therapy for the treatment and prophylaxis of cardiac and circulatory diseases.
La présente invention concerne une composition pharmaceutique à libération contrôlée administrée par voie orale pour une thérapie à dose quotidienne unique en traitement et prévention de troubles cardiaques et circulatoires, ladite composition comprenant du carvédilol ou un sel ou un ester pharmaceutiquement acceptable de celui-ci, ainsi que des excipients contrôlant le taux de libération. Cette composition est conçue pour libérer le carvédilol de manière contrôlée de façon à pouvoir contrôler la concentration plasmique en carvédilol, de telle sorte que le rapport entre la concentration plasmique maximale et la concentration plasmique 24 heures après administration, ainsi que le temps moyen de séjour du carvédilol se trouvent dans une plage désirée pour cette thérapie à dose quotidienne unique en traitement et prévention de troubles cardiaques et circulatoires.
Chary Bala Ramesha R.
Shanghvi Dilip Shantilal
Tyebji Ziauddin Z.
Riches Mckenzie & Herbert Llp
Sun Pharmaceutical Industries Limited
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