Oral cyclosporin formulations

Details Oral cyclosporin formulations Oral cyclosporin formulations

A - Human Necessities

61

K

A61K 38/13 (2006.01) A61K 9/00 (2006.01) A61K 9/48 (2006.01) A61K 47/00 (2006.01) A61K 47/08 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61K 47/26 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2275773

Improved oral cyclosporin formulations which have high bioavailability and are capable of administration in both liquid and hard capsule form are provided. In the subject formulations, cyclosporin is delivered in an orally acceptable vehicle comprising at least one alkanol solvent of from 2 to 3 carbon atoms in combination with at least one non-ionic surfactant. The subject formulations may further comprise at least one cosolvent, where cosolvents of interest include fatty acids and diols. The subject formulations find use in immuno- suppressive therapy.

Cette invention concerne des formulations de cyclosporine orale améliorées qui se caractérisent par une biodisponibilité élevée et qui sont capables d'être administrées à la fois sous forme liquide et sous forme de capsule solide. Dans les formulations de cette invention, la cyclosporine est apportée dans un véhicule acceptable par voie orale comprenant au moins un solvant alcanol contenant entre 2 et 3 atomes de carbone combiné à au moins un tensioactif non ionique. Ces formulations peuvent également comprendre au moins un cosolvant, les cosolvants adaptés étant les acides gras et les diols. Les formulations de cette invention peuvent être utilisées dans le traitement aux agents immunosuppresseurs.

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