Oral delivery of protein drug using microemulsion

Details Oral delivery of protein drug using microemulsion Oral delivery of protein drug using microemulsion

A - Human Necessities

61

K

A61K 9/107 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2672707

A novel method of encapsulating a drug, preferably a peptide and/or protein drug in a biodegradable complex, which comprises: a) a biodegradable polymer that contains primary amine groups such as chitosan oligosaccharide, b) an organic carboxylic acid such as oleic acid, and c) optionally, an emulsifying agent such as plurol (glycerol-6-dioleate). The formula results in the formation of a continuous oily phase containing nanoparticles having the drug encapsulated therein.

L'invention concerne un nouveau procédé pour encapsuler un médicament, de préférence un peptide et/ou un médicament protéique dans un complexe biodégradable, qui comprend: a) un polymère biodégradable qui contient des groupes aminés primaires tels que l'oligosaccharide de chitosane, b) un acide carboxylique organique tel que l'acide oléique et c) éventuellement un agent émulsifiant tel qu'un plurol (glycérol-6-dioléate). La formule permet de former une phase huileuse continue qui contient des nanoparticules dans lesquelles est encapsulé le médicament.

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