A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/70 (2006.01) A61K 31/155 (2006.01) A61K 31/19 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2519038
The present invention provides an oral delivery system for the treatment of periodontal disease, being in a solid unit dosage form for administration to a patient and comprising: (i) a biodegradable or bioerodible pharmaceutically acceptable polymer; (ii) a therapeutically effective amount of at least one antibacterial agent; and (iii) a therapeutically effective amount of at least one anti-inflammatory agent, the relative weight ratio between the antibacterial agent and the anti-inflammatory agent ranking from about 7:1 to about 1:5. The system may further comprise at least one of a cross-linking agent, a plasticizing agent, a wetting agent, a suspending agent, a surfactant and a dispersing agent.
L'invention concerne un système d'administration par voie orale pour le traitement d'une maladie parodontale, qui se présente sous une forme galénique unitaire solide destinée à être administrée à un patient. Ce système comprend : (1) un polymère pharmaceutiquement acceptable, biodégradable ou bioérodable ; (2) une quantité thérapeutiquement efficace d'au moins un agent antibactérien ; et (3) une quantité thérapeutiquement efficace d'au moins un agent anti-inflammatoire, le rapport en poids entre l'agent antibactérien et l'agent anti-inflammatoire se situant entre environ 7:1 et environ 1:5. Ce système peut comprendre en outre au moins un agent de réticulation, un agent plastifiant, un agent mouillant, un agent de suspension, un tensioactif et un agent dispersant.
Oren Dan
Penhasi Adel
Reuveni Albert
Dexcel Pharma Technologies Ltd.
Smart & Biggar
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