A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4035 (2006.01) A61K 9/20 (2006.01) A61K 47/10 (2006.01) A61K 47/26 (2006.01) A61K 47/32 (2006.01) A61K 47/36 (2006.01) A61K 47/38 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2658549
Provided is an oral disintegrating tablet comprising mitiglinide calcium hydrate, which shows reduced bitter taste and rapid disintegrating properties in an oral cavity and can be dissolved in a digestive tract rapidly. The oral disintegrating tablet comprises a) mitiglinide calcium hydrate, b) crystalline cellulose, c) at least one member selected from the group consisting of an aminoalkyl methacrylate copolymer E, polyvinylacetal diethylaminoacetate, an ethyl acrylate/methyl methacrylate copolymer and ethylcellulose as a masking agent, d) a sugar or a sugar alcohol, and e) at least one member selected from corn starch and partially gelatinized starch, and has masked bitter taste.
L'invention concerne un comprimé à désagrégation orale, comprenant du mitiglinide calcium hydraté, qui présente un goût amer réduit et des propriétés de désagrégation rapide dans la cavité orale qui se dissout rapidement dans le système digestif. Le comprimé à désagrégation orale comprend a) du mitiglinide calcium hydraté, b) de la cellulose cristalline, c) comme agent de masquage, au moins un élément choisi dans le groupe constitué par un copolymère d'éthylène et de méthacrylate d'aminoalkyle, le diéthylaminoacétate de polyvinylacétal, un copolymère d'acrylate d'éthyle et de méthacrylate de méthyle et l'éthylcellulose, d) un sucre ou un alcool de sucre, et e) au moins un élément choisi parmi l'amidon de maïs et l'amidon partiellement gélatinisé. Ce comprimé a un goût amer masqué.
Kanada Ken
Mimura Kazuki
Takeda Yasuhiro
Kirby Eades Gale Baker
Kissei Pharmaceutical Co. Ltd.
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