A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/711 (2006.01) A61K 39/29 (2006.01) C12N 5/10 (2006.01) C12N 15/40 (2006.01) C12N 15/51 (2006.01)
Patent
CA 2380471
The present invention provides an oral DNA composition for improving an impaired immunity associated with chronic infection of hepatitis B virus (HBV) comprising an attenuated strain of bacterial cells which preferentially target phagocytic cells of the intestinal mucosa, and which serve as a vehicle for a plasmid vector carrying one or more genes or complementary DNA coding for at least a portion of a hepatitis B viral protein or peptide. Given orally, the DNA composition causes a transient and self-limiting infection of the intestinal tract through autolysis of the bacterial cells and release of the plasmid after gaining entry into infected host cells. A promotor contained within the plasmid allows for expression of the HBV gene(s) in the eurokaryotic environment, the viral products of which help to booster a cell- mediated immunity to clear the infection and reverse a state of immune tolerance characteristic of HBV chronic infection.
Ng Mun-Hon
Yuen Kwok-Yung
Zheng Bo-Jian
G. Ronald Bell & Associates
The University Of Hong Kong
LandOfFree
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