Oral dosage form comprising rosiglitazone

Details Oral dosage form comprising rosiglitazone Oral dosage form comprising rosiglitazone

A - Human Necessities

61

K

A61K 31/427 (2006.01) A61K 9/16 (2006.01) A61K 9/48 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2595409

An oral dosage form comprising pellets of a first composition and pellets of a second composition, each composition comprising 5-[4-[2-(N-methyl-N-(2 pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione or a pharmaceutically acceptable salt or solvate thereof and a pharmaceutically acceptable carrier therefor, wherein the first and second compositions are arranged to release drug at differing release rates on administration, preferably such that the rate of release of the drug from the dosage form is substantially independent of pH; a process for preparing such a dosage form and the use of such a dosage form in medicine.

L'invention concerne une forme posologique orale comprenant des granules d'une première composition et des granules d'une seconde composition, chaque composition contenant une 5-[4-[2-(N-méthyl-N-(2 pyridyl)amino)éthoxy]benzyl]thiazolidine-2,4-dione ou un sel ou solvate pharmaceutiquement acceptable de cette dernière et un vecteur pharmaceutiquement acceptable pour ledit composé, les première et seconde compositions étant conçues pour libérer le médicament à différentes vitesses de libération lors de l'administration, de préférence de sorte que la vitesse de libération du médicament de la forme posologique est sensiblement indépendante du pH. Cette invention concerne également un procédé de préparation d'une forme posologique de ce type et l'utilisation de cette forme posologique en médecine.

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