Oral dosage form comprising rosiglitazone

Details Oral dosage form comprising rosiglitazone Oral dosage form comprising rosiglitazone

A - Human Necessities

61

K

A61K 31/427 (2006.01) A61K 9/20 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2595411

An oral dosage form, such as a bilayer tablet, comprising a first layer of a first composition and a second layer of a second composition, each composition comprising 5-[4-[2-(N-methyl-N-(2 pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4- dione or a pharmaceutically acceptable salt or solvate thereof, ('the drug') and a pharmaceutically acceptable carrier therefor, wherein the first and second compositions are arranged to release drug at differing release rates on administration; a process for preparing such a dosage form; and the use of such a dosage form in medicine.

La présente invention concerne une forme posologique orale telle qu'un comprimé bicouche, comprenant une première couche d'une première composition et une seconde couche d'une seconde composition. Chaque composition comprend comme principe actif du 5-[4-[2-(N-méthyl-N-(2 pyridyl)amino)éthoxy]benzyl]thiazolidine-2,4-dione, ou l'un de ses sels ou solvates pharmaceutiquement admis, et un excipient correspondant pharmaceutiquement admis. En l'occurrence, les deux compositions sont agencées de façon à libérer le principe actif à des vitesses différentes. L'invention concerne également un procédé d'élaboration d'une telle forme posologique et l'utilisation de telles formes posologiques en médecine.

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