Oral dosage form for controlled drug release

Details Oral dosage form for controlled drug release Oral dosage form for controlled drug release

A - Human Necessities

61

K

A61K 9/44 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2475544

An oral dosage form comprising, (i) an erodable core, which core comprises a pharmaceutically active weak base or a pharmaceutically acceptable salt or solvate thereof; and (ii) an erodable coating surrounding said core, which coating comprises one or more openings extending substantially completely through said coating but not penetrating said core and communicating from the environment of use to said core; characterised in that release of the pharmaceutically active weak base or a pharmaceutically acceptable salt or solvate thereof from the dosage form occurs through the said opening(s) by the erosion of said erodable core and through erosion of said erodable coating under pre-determined pH conditions; a process for preparing such a dosage form and the use of such a dosage form in medicine.

L'invention concerne une forme galénique orale qui comprend (i) un noyau érodable, ce noyau comprenant une base faible pharmaceutiquement active ou un sel ou solvate pharmaceutiquement acceptable de celle-ci, et (ii) une enveloppe érodable entourant ledit noyau, cette enveloppe comprenant une ou plusieurs ouvertures s'étendant sensiblement sur toute l'épaisseur de l'enveloppe, sans pénétrer dans le noyau, et reliant ledit noyau à l'environnement d'utilisation. L'invention se caractérise en ce que la base faible pharmaceutiquement active ou le sel ou solvate pharmaceutiquement acceptable de cette base est libéré de la forme galénique à travers lesdites ouvertures par érosion du noyau et de l'enveloppe érodables dans des conditions de pH prédéterminées. L'invention concerne également un procédé de préparation de cette forme galénique et l'utilisation de celle-ci dans le domaine médical.

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