Oral dosage form safeguarded against abuse

Details Oral dosage form safeguarded against abuse Oral dosage form safeguarded against abuse

A - Human Necessities

61

K

A61K 9/22 (2006.01) A61K 31/135 (2006.01)

Patent

CA 2572491

The invention relates to an oral dosage form, which is safeguarded against abuse and which has a controlled opioid release for a once daily administering. The invention is characterized in that the oral dosage form comprises at least one opioid with an abuse potential (A), at least one synthetic and/or natural polymer (C), optionally comprises retarding matrix materials, physiologically compatible adjuvants (B), optionally comprises a wax (D), and optionally comprises at least one retarding coating. Constituents (C) or (D) each have a breaking resistance of at least 500 N, preferably at least 750 N.

L'invention concerne une forme posologique anti-abus pour administration par voie orale, à libération contrôlée d'opioïde, à administrer une fois par jour, qui se caractérise en ce qu'elle contient au moins un opioïde présentant un certain potentiel d'abus (A), au moins un polymère (C) synthétique et/ou naturel, éventuellement des matières matricielles de retardement, des adjuvants (B) physiologiquement compatibles, éventuellement une cire (D) et éventuellement au moins un revêtement de retardement, les composants (C) et (D) présentant respectivement une résistance à la rupture d'au moins 500 N, de préférence d'au moins 750 N.

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