Oral dosage formulation

Details Oral dosage formulation Oral dosage formulation

A - Human Necessities

61

K

A61K 9/24 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2554012

A multi-layer oral dosage form, preferably a tablet, comprising a matrix core comprising a therapeutically effective amount of a first drug (NSAID), wherein the matrix core allows sustained release of the first drug; a first layer, which is in contact with the matrix core, comprising a first portion of a pharmaceutically effective amount of a second drug (H2~-blocker antagonist) , wherein the first layer allows sustained release of the second drug; and a second layer, which is in contact with said matrix core, comprising a second portion of the second drug, wherein the second layer allows immediate release of the second drug. Methods for preparing the multi-layer dosage form are also disclosed.

L'invention concerne une forme de dosage oral multicouche, de préférence un comprimé, comprenant un noyau matriciel qui renferme une quantité thérapeutiquement efficace d'un premier médicament (NSAID), ledit noyau matriciel permettant la libération lente de ce premier médicament; une première couche en contact avec le noyau matriciel comprenant une première partie d'une quantité thérapeutiquement efficace d'un second médicament (antagoniste inhibant H¿2?), ladite première couche permettant la libération prolongée de ce second médicament; et une seconde couche en contact avec le noyau matriciel comprenant une seconde partie du second médicament, ladite seconde couche permettant la libération immédiate de ce second médicament. L'invention concerne également des procédés permettant de préparer la forme de dosage multicouche.

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