Oral dosage from comprising a liquid active agent...

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/00 (2006.01) A61K 9/48 (2006.01) A61K 31/167 (2006.01) A61K 31/57 (2006.01)

Patent

CA 2490412

The present invention provides a controlled release oral dosage form for the delivery of a liquid active agent formulation. The dosage form of the present invention includes a reservoir formed of a water impermeable material and filled with a liquid active agent formulation. The dosage form of the present invention also includes an expandable osmotic composition positioned within the reservoir, and optionally, the expandable osmotic composition is separated from contact with the liquid active agent formulation by a barrier layer that is substantially impermeable to the passage of liquid. To facilitate expulsion of the liquid active agent formulation, the dosage form of the present invention also includes an exit orifice. The material make-up and design of the reservoir included in the dosage form of the present invention allow the manufacture of an oral dosage form capable of more consistently achieving a desired release rate or release rate profile of active agent from a liquid formulation.

L'invention concerne une forme posologique orale à libération prolongée permettant l'administration d'une préparation de principe actif liquide. La forme posologique décrite dans cette invention comprend un réservoir constitué d'un matériau imperméable à l'eau et rempli d'une préparation de principe actif liquide. Cette forme posologique comprend également une composition osmotique expansible disposée à l'intérieur du réservoir; cette composition osmotique expansible est, éventuellement, isolée du contact avec la préparation de principe actif liquide par l'intermédiaire d'une couche barrière essentiellement imperméable au passage du liquide. Afin de faciliter l'expulsion de la préparation de principe actif liquide, la forme posologique décrite dans l'invention comprend également un orifice de sortie. La conception et la fabrication du matériau constituant le réservoir se trouvant dans la forme posologique permettent d'élaborer une forme posologique orale capable d'assurer plus efficacement une vitesse de libération souhaitée ou un profil de vitesse de libération du principe actif depuis la préparation liquide.

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