Oral drugs and functional foods for treating and preventing...

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/39 (2006.01) A23L 1/305 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2224709

Oral drugs and functional foods of the present invention contain type-II collagen denatured (fragmented) under specific conditions. Rheumatoid arthritis (RA) has been considered to be an autoimmune disease against type--II collagen as an antigen. Since denatured type-II collagen of the invention induces high oral immune tolerance and inhibits immune responses against type-II collagen, it can prevent and treat RA. Particularly, RA can effectively be prevented and treated by simple oral administration of type-II collagen.

La présente invention concerne un médicament à administration par voie orale contre la polyarthrite rhumatoïde et un aliment actif comprenant chacun un collagène de type II qui a été dénaturé (fragmenté) dans des conditions spécifiques. On suppose que la polyarthrite rhumatoïde est une affection auto-immune dans laquelle le collagène de type II intervient comme antigène. Grâce à sa tolérogénicité élevée en cas d'administration par voie orale, le collagène de type II dénaturé supprime la réponse immunitaire au collagène de type II et permet la prévention et le traitement de la polyarthrite rhumatoïde. Cette administration commode par voie orale permet ainsi d'utiliser ce médicament pour la prévention et le traitement de la polyarthrite rhumatoïde.

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