A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7056 (2006.01) A61K 9/20 (2006.01) A61K 9/32 (2006.01) A61K 9/50 (2006.01) A61K 47/32 (2006.01) A61K 47/36 (2006.01)
Patent
CA 2520321
The present invention is directed to an extended release multiparticulate formulation of a therapeutic agent, wherein coated core multiparticulate particles of the therapeutic agent are overcoated with a binder-dispersing agent, such as povidone or cross-povidone. The invention is also directed to compressed tablets of the extended release multiparticulate formulation of the invention, and to a method of oral administration of compressed tablets of clindamycin to a subject to treat or prevent a gram-positive bacterial infection therein. The binder-dispersing agent in the formulations of the present invention ensure that compressed tablets formed therefrom will remain intact through oral administration, and dissolve shortly thereafter, enabling the multiparticulates to release the therapeutic agent contained therein over an extended period of time.
La prEsente invention concerne une formulation multiparticulaire d'un agent thErapeutique A libEration prolongEe, dans laquelle les particules multiparticulaires du noyau enrobE de l'agent thErapeutique sont recouvertes d'un agent de dispersion de liants, tel que la povidone ou la trans-povidone. L'invention concerne Egalement des tablettes comprimEes de ladite formulation multiparticulaire, et une mEthode d'administration par voie orale de tablettes comprimEes de clindamycine A un sujet pour traiter ou pour prEvenir chez celui-ci une infection bactErienne A Gram positif. GrAce A l'agent de dispersion de liants contenu dans lesdites formulations, les tablettes comprimEes formEes A partir de ces derniEres vont demeurer intactes lors de l'administration par voie orale, et se dissoudre peu aprEs, permettant ainsi aux formulations multiparticulaires de libErer, sur une durEe prolongEe, l'agent thErapeutique qu'elles contiennent.
Heimlich John M.
Lee Ernest J.
Noack Robert M.
Pharmacia Corporation
Smart & Biggar
LandOfFree
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