Oral fast-dissolving compositions for dopamine agonists

Details Oral fast-dissolving compositions for dopamine agonists Oral fast-dissolving compositions for dopamine agonists

A - Human Necessities

61

K

A61K 31/485 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01)

Patent

CA 2229597

This invention relates to a pharmaceutical composition for oral administration comprising a earner and, as active ingredient, a dopamine agonist, characterised in that the composition is in the form of a fast-dispersing dosage form designed rapidly to release the active ingredient in the oral cavity. Such compositions which further comprise an anti-emetic and/or an opioid antagonist are also provided. A process for preparing such compositions, the use of such compositions for the treatment and/or evaluation of Parkinson's disease and products and kits for the administration of a dopamine agonist and the co- administration of a dopamine agonist and an anti-emetic and/or opioid antagonist are also provided.

L'invention concerne une composition pharmaceutique prévue pour être administrée par voie orale. Cette composition comprend un excipient et, comme principe actif, un agoniste de la dopamine. Cette composition se caractérise en ce qu'elle se présente sous une forme à dispersion rapide prévue pour libérer rapidement le principe actif dans la cavité buccale. L'invention concerne également des compositions qui comprennent, en outre, un anti-émétique et/ou un antagoniste des opioïdes. L'invention a aussi pour objet un procédé pour préparer ce type de compositions, l'utilisation de ces compositions pour traiter et/ou évaluer la maladie de Parkinson et des produits et des kits prévus pour administrer un agoniste de la dopamine et pour administrer conjointement un agoniste de la dopamine et un anti-émétique et/ou un antagoniste des opioïdes.

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