A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/40 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 31/495 (2006.01) A61K 47/10 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2170622
The present invention concerns a formulation for oral administration comprising an antifungal, a sufficient amount of a cyclodextrin or a derivative thereof, an aqueous acidic medium as bulk liquid carrier and an alcoholic co-solvent. Addition of one or more pharmaceutically acceptable sweeteners and one or more pharmaceutically acceptable flavours thereto yields palatable oral formulations. A process of preparing such formulations and pharmaceutical dosage forms comprising said formulations.
L'invention concerne une formulation destinée à l'administration orale comprenant un antifongique, une quantité suffisante d'une cyclodextrine ou un des dérivés de celle-ci, un milieu aqueux acide en tant qu'excipient liquide de volume important, ainsi qu'un solvant additionnel à base d'alcool. En ajoutant un ou plusieurs édulcorants et agents de saveur acceptables sur le plan pharmaceutique, on obtient des formulations orales agréables au goût. L'invention concerne également un procédé de préparation de ces formulations ainsi que les formes à dosage pharmaceutique les comprenant.
Dries Willy Maria Albert Carlo
Francois Marc Karel Jozef
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica Naamloze Vennootschap
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