Oral gastrointestinal diagnostic x-ray contrast agents in...

A - Human Necessities – 61 – K

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A61K 49/04 (2006.01) A61K 9/16 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2206961

Nanoparticulate crystalline substances formulated with stabilizers and pharmaceutically acceptable clays to enhance contact between the crystalline substances and the gastrointestinal tract. These formulations have improved safety profiles, a low potential for absorption, are not viscous and not contraindicated for GI perforations or intestinal obstructions. The properties of the surfactant stabilizers are independent of the crystalline drug used and largely determine the extent to which the formulation coats the GI tract.

L'invention porte sur des substances cristallines nanoparticulaires associées à des stabilisateurs et à des argiles pharmacocompatibles en vue de renforcer le contact entre lesdites substances et le tractus digestif. Ces préparations présentent un profil plus sûr, un faible potentiel d'absorption, ne sont pas visqueuses et ne sont pas contre-indiquées en cas de perforations gastro-intestinales ou d'occlusion intestinale. Les propriétés de ces stabilisateurs tensioactifs sont indépendantes du type de médicament cristallin utilisé et conditionnent largement le degré d'adhérence des préparations susdites au tractus digestif.

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