Oral gram(+) bacteria and glutamine composition for...

A - Human Necessities – 01 – N

Patent

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Details

A01N 37/18 (2006.01) A61K 31/195 (2006.01) A61K 35/74 (2006.01) C12N 1/20 (2006.01)

Patent

CA 2407724

A composition and method for treating and preventing gastro-intestinal injury are disclosed. The composition includes a combination of Gram (+) bacteria, in particular <i>Lactobacillus</i> and/or <i>Bifidobacteria</i>, and glutamine. The method involves orally or naso-gastrically administering a composition containing Gram (+) bacteria, in particular <i>Lactobacillus</i>, and glutamine. The composition, which blocks translocation of bacterial agents such as Gram (-) bacteria, other infectious agents, toxins, chemicals and injurious substances, may be used in the prevention and treatment of symptoms and/or disease that result from translocation of Gram (-) bacteria, including inflammation in the gastro-intestinal tract, Neonatal Necrotizing Enterocolitis (NEC) and bacterial sepsis.

L'invention concerne une composition et une méthode de traitement et de prévention de troubles gastro-intestinaux. La composition comprend une combinaison de bactéries Gram (+), en particulier <i>Lactobacillus</i> et/ou <i>Bifidobacteria</i>, et de glutamine. La méthode consiste à administrer oralement ou par voie naso-gastrique une composition contenant des bactéries Gram (+), en particulier <i>Lactobacillus</i>, et de glutamine. La composition, qui bloque la translocation d'agents bactériens tels que des bactéries Gram(-), assurant une protection contre d'autres agents infectieux, des toxines, des produits chimiques et des substances dangereuses, peut être utilisée dans la prévention et le traitement de symptômes et/ou de maladies qui résultent de la translocation de bactéries Gram(-), comprenant l'inflammation du tractus gastro-intestinal, l'entérocolite nécrosante néonatale et la sepsie bactérienne.

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