Oral liquid tolterodine composition

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/137 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 47/00 (2006.01) A61P 13/10 (2006.01)

Patent

CA 2496806

A pharmaceutical composition in a form of an orally deliverable liquid comprises water having in solution therein a pharmaceutically acceptable water- soluble salt of a tolterodine related compound at a therapeutically effective concentration in the composition. The composition has a pH of about 2 to about 6 and further comprises a sweetening agent and an antimicrobial agent at a concentration that is antimicrobially effective at the pH of the composition. The composition is useful for treating a muscarinic receptor mediated disorder, more particularly overactive bladder, in a subject by orally administering to the subject a therapeutically effective amount of the composition.

L'invention concerne une composition pharmaceutique sous forme d'un liquide administré par voie orale. Cette composition comprend de l'eau contenant une solution d'un sel d'un composé associé à la toltérodine, pharmaceutiquement acceptable et soluble dans l'eau, à une concentration efficace sur le plan thérapeutique. Cette composition présente un pH d'environ 2 à environ 6 et comprend également un agent édulcorant et un agent antimicrobien à une concentration efficace sur le plan antimicrobien au pH de la composition. Par ailleurs, cette composition convient au traitement, chez un sujet, d'un trouble médié par le récepteur muscarinique, en particulier la vessie hyperactive, par administration orale d'une quantité, efficace sur le plan thérapeutique, de la composition.

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