A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/47 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 31/4709 (2006.01)
Patent
CA 2325636
The invention relates to solid medicinal preparations having a multiphase structure for oral administration, which contain gatifloxacin or pharmaceutically suitable salts or hydrates thereof, as well as additives from the group including fillers, binding agents, lubricants, disintegrating agents or mixtures thereof. The inner phase contains the active ingredient gatifloxacin or pharmaceutically suitable salts or hydrates thereof, additives from the group including binding agents, fillers, disintegrating agents or mixtures thereof and at least one outer phase consists of at least one disintegrating agent as well as other additives selected from a group containing at least one lubricant and possibly fillers and/or possibly binding agents. The invention also relates to a method for producing said solid medicinal preparation.
L'invention concerne des formes galéniques solides à structure multiphase, pour administration orale, qui contiennent de la gatifloxacine ou des sels ou des hydrates utilisables au plan pharmaceutique, ainsi que des auxiliaires du groupe comprenant les charges, les liants, les lubrifiants, les accélérateurs de désintégration ou des mélanges de ces différents constituants. La phase intérieure contient le principe actif gatifloxacine ou ses sels ou hydrates utilisables au plan pharmaceutique, des auxiliaires du groupe comprenant des liants, des charges, des accélérateurs de désintégration ou des mélanges desdits constituants et au moins une phase extérieure présentant au moins un accélérateur de désintégration et d'autres auxiliaires du groupe comprenant au moins un lubrifiant, éventuellement des charges et/ou éventuellement des liants. L'invention concerne en outre des procédés de préparation desdites formes galéniques solides.
Bartholomaus Johannes
Betzing Jurgen
Fetherstonhaugh & Co.
Gruenenthal Gmbh
Kyorin Pharmaceutical Co. Ltd.
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