Oral mopidamol preparations

A - Human Necessities – 61 – K

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167/219

A61K 31/505 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01)

Patent

CA 1228546

Abstract The specification describes new mopidamol preparations for oral adminis- tration, having substantially better bioavailability and considerably reduced fluctuations in blood levels, these preparations containing, for 1 mol of mopidamol, at least one equivalent of an orally acceptable acidic excipient, the active substance and excipient preferably being intimately mixed. Other excipi- ents may also be incorporated such as diffusion lacquers which are permeable to gastrointestinal fluid, swellable water-soluble polymers, water-insoluble poly- mers and water-repellent fats. Processes for producing these preparations are also described. Mopidamol is more accurately described as (2,6-bis(diethanol- amuno)-4-piperidino-pyrimido[5,4-d]pyrimidine).

438670

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