Oral morphine multiparticulate formulation

Details Oral morphine multiparticulate formulation Oral morphine multiparticulate formulation

A - Human Necessities

61

K

A61K 31/485 (2006.01) A61K 9/00 (2006.01) A61K 9/50 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2306333

An oral morphine multiparticulate formulation for once-daily administration to a patient, comprising sustained release particles each having a core containing water soluble morphine and an osmotic agent, the core being coated with a rate-controlling polymer coat comprised of ammonio methacrylate copolymers in an amount sufficient to achieve therapeutically effective plasma levels of morphine over at least 24 hours in the patient.

L'invention concerne une formulation multiparticulaire de morphine orale destinée à être administrée une fois par jour à un patient. Cette formulation comprend des particules à libération prolongée, chacune présentant une partie centrale renfermant de la morphine hydrosoluble et un agent osmotique. La partie centrale est revêtue d'un polymère contrôlant la vitesse constitué de copolymères méthacryliques ammoniacaux en quantité suffisante pour atteindre des concentrations plasmiques de morphine thérapeutiquement efficaces pendant au moins 24 heures chez un patient.

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