A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/10 (2006.01) A61K 9/00 (2006.01) A61K 47/02 (2006.01) A61K 47/36 (2006.01)
Patent
CA 2338688
The present invention relates to mucoadhesive compositions comprising a safe and effective amount of a gastrointestinal active; from about 1.5 % to about 10 %, by weight of the composition, of a clay component; and from about 0.01 % to about 1 %, by weight of the composition, of a gum component. Alternatively, the clay component can be a titanium dioxide or a silicone dioxide component. The mucoadhesive compositions also preferably comprise up to about 2 % by weight of the composition, of a non-ionic component such as methyl cellulose. The present invention also relates to methods of prevention and treatment of gastrointestinal tract disorders in humans or lower animals by orally administering a composition of the present invention.
La présente invention concerne des compositions mucoadhésives renfermant une dose sure et efficace d'une substance active au niveau gastro-intestinal; de 1,5 % à 10 % environ, en poids de la composition, d'une composante argile; et de 0,01 % à 1 %, en poids de la composition, d'une composante gomme. En variante, la composante argile peut être remplacée par une composante à base de dioxyde de titane ou de dioxyde de silicium. De plus, ces compositions mucoadhésives doivent de préférence renfermer jusqu'à 2 % en poids d'un composé non ionique tel que de la cellulose de méthyle. L'invention concerne également des méthodes de prévention et de traitement de troubles de l'appareil gastro-intestinal chez l'homme et les animaux par administration orale de la composition selon l'invention.
Desai Kishorkumar Jivanlal
Dobrozsi Douglas Joseph
Mayer Christopher Robert
Vienneau Todd Ehren
Kirby Eades Gale Baker
The Procter & Gamble Company
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