Oral mucosal dosage forms of apomorphine

Details Oral mucosal dosage forms of apomorphine Oral mucosal dosage forms of apomorphine

A - Human Necessities

61

K

A61K 31/485 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2394297

A pharmaceutical formulation for the prolonged-release oral mucosal administration of apomorpine which comprises a therapeutically effective amount of apomorphine or a pharmaceutically acceptable salt or pro-drug thereof in combination with a carrier comprising from about 10 percent by weight to about 95 percent by weight dextran, based upon the total weight of the formulation. In one embodiment of the invention, dextran having a molecular weight in the range between about 5000 Daltons and 100,000 Daltons is the sole component of the formulation for prolonging the release of the active drug component. In an alternative embodiment, a mixture of microcrystalline cellulose and dextran act as the components to prolong the release of apomorphine.

L'invention concerne une formulation pharmaceutique destinée à l'administration orale par voie muqueuse à libération prolongée d'apomorphine. Cette formulation contient une dose efficace d'apomorphine ou un sel ou un promédicament pharmaceutiquement acceptable dudit composé en combinaison avec un support comprenant entre environ 10 % en poids et environ 95 % en poids de dextrane, sur la base du poids total de cette formulation. Dans un mode de réalisation de l'invention, le dextrane présentant un poids moléculaire variant entre 5000 Daltons et 100 000 Daltons est le seul composant de cette formulation qui permet de prolonger la libération du composant médicamenteux actif. Dans un autre mode de réalisation, un mélange de cellulose microcristalline et de dextrane tient lieu de composant prolongeant la libération d'apomorphine.

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