Oral osmotic dosage form having a high flux membrane

Details Oral osmotic dosage form having a high flux membrane Oral osmotic dosage form having a high flux membrane

A - Human Necessities

61

K

A61K 9/28 (2006.01)

Patent

CA 2596029

Disclosed are oral osmotic dosage forms and methods wherein a semipermeable membrane of the oral osmotic dosage form includes from about 23 wt% to about 50 wt% of a flux enhancer and from about 0.01 wt% to about 5 wt% of antioxidant, based on the total dry weight of the semi-permeable membrane. Such compositions provide high flux membranes with improved mechanical and transport stability during storage on the shelf.

L'invention concerne des formes galéniques osmotiques orales et des procédés associés, une membrane semi-perméable de ladite forme comprenant entre environ 23 % en poids et environ 50 % en poids d'un amplificateur de flux et entre environ 0,01 % en poids et environ 5 % en poids d'un antioxydant, en fonction du poids total à sec de la membrane semi-perméable. De telles compositions mettent en place des membranes à flux élevé à stabilités mécanique et de transport améliorées pendant le stockage sur les rayons.

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