Oral pharmaceutical coated composition for pulsatile release

Details Oral pharmaceutical coated composition for pulsatile release Oral pharmaceutical coated composition for pulsatile release

A - Human Necessities

61

K

A61K 9/36 (2006.01)

Patent

CA 2644699

A pharmaceutical composition comprising a pharmaceutically active agent, a core, a coating comprising an inner film comprising cellulose acetate and hydroxypropylmethylcellulose in a ratio of cellulose acetate : hydroxypropylmethylcellulose of 80 % to 99.5 % : 0.5 % to 20 % and an outer film comprising ethylcellulose and hydroxypropylcellulose in a ratio of ethylcellulose : hydroxypropylcellulose of 50 % to 80 % : 20 % to 50 %.

La présente invention concerne une composition pharmaceutique contenant un principe pharmaceutiquement actif, un noyau et un revêtement constitué d'une pellicule interne à base d'acétate de cellulose et d'hydroxypropylméthylcellulose présentant une proportion de 80 % à 99,5 % d'acétate de cellulose pour 0,5 % à 20 % d'hydroxypropylméthylcellulose, et d'une pellicule externe à base d'éthylcellulose et d'hydroxypropylcellulose présentant une proportion de 50 % à 80 % d'éthylcellulose pour 20 % à 50 % d'hydroxypropylcellulose.

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