Oral pharmaceutical composition containing a block copolymer

Details Oral pharmaceutical composition containing a block copolymer Oral pharmaceutical composition containing a block copolymer

A - Human Necessities

61

K

A61K 47/34 (2006.01) A61K 9/51 (2006.01) A61P 7/02 (2006.01) A61K 9/107 (2006.01) A61K 9/14 (2006.01) A61K 9/48 (2006.01)

Patent

CA 2428784

The invention relates to oral pharmaceutical compositions that comprise a water miscible micelle forming block copolymer and a compound. The copolymer can be a diblock copolymer of formula AB or BA. The copolymer could also be triblock copolymer of formula ABA or BAB, or a multiblock copolymer having repeating BA or AB units of formula A(BA)n or B(AB)n, where n is an integer. The A-block may be poly(L-lactide) or poly(D-, L-, or DL-lactic acid) and the B-block a polyethylene glycol.

L'invention concerne des compositions pharmaceutiques administrées par voie orale qui comportent un copolymère séquencé formant des micelles miscibles avec l'eau et un composé. Le copolymère peut être un copolymère dibloc de formule AB ou BA. Le copolymère pourrait également être un copolymère tribloc de formule ABA ou BAB, ou un copolymère multibloc comportant des unités BA ou AB répétitives, de formule A(BA)n ou B(AB)n, dans lesquelles n est un nombre entier. Le bloc A peut être un poly(L-lactide) ou un poly(acide D-,L-, ou DL-lactique) et le bloc B, un polyéthylène glycol.

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