Oral pharmaceutical dosage forms comprising a proton pump...

A - Human Necessities – 61 – K

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A61K 31/44 (2006.01) A61K 9/20 (2006.01) A61K 9/24 (2006.01) A61K 9/26 (2006.01) A61K 9/28 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01) A61K 31/19 (2006.01) A61K 31/54 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2213987

An oral pharmaceutical dosage form comprising an acid susceptible proton pump inhibitor and one or more NSAIDs in a fixed formulation, wherein the proton pump inhibitor is protected by an enteric coating layer. The fixed formulation is in the form of an enteric coating layered tablet, a capsule or a multiple unit tableted dosage form. The multiple whit dosage forms are most preferred. The new fixed formulation is especially useful in the treatment of gastrointestinal side-effects associated with NSAID treatment.

Forme galénique pharmaceutique pour administration orale comprenant un inhibiteur de pompe à protons sensible à l'acide et/ou plusieurs médicaments inflammatoires non stéroïdiens sous une formulation fixe, l'inhibiteur de pompe à protons étant protégé par une couche d'enrobage gastro-résistante. La formulation fixe se présente sous la forme d'un comprimé à enrobage gastro-résistant, d'une capsule ou d'une forme galénique en comprimés à plusieurs unités. La présentation sous une forme à plusieurs unités est la présentation préférée. Cette nouvelle formulation fixe se révèle particulièrement utile pour le traitement des effets secondaires gastro-intestinaux associés au traitement par anti-inflammatoires non stéroïdiens.

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