Oral pharmaceutical preparation for colon-specific delivery

Details Oral pharmaceutical preparation for colon-specific delivery Oral pharmaceutical preparation for colon-specific delivery

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/56 (2006.01) A61K 47/02 (2006.01) A61K 47/32 (2006.01) A61K 47/36 (2006.01) A61P 1/00 (2006.01) A61P 1/04 (2006.01) A61P 3/10 (2006.01) A61P 5/00 (2006.01) A61P 5/44 (2006.01) A61P 7/12 (2006.01) A61P 15/04 (2006.01) A61P 19/10 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2684655

An oral pharmaceutical preparation excellent in the ability to deliver a drug to the large intestine, more specifically, an oral pharmaceutical preparation for delivering a drug to the large intestine which comprises a core containing a pharmaceutically acceptable filler as the essential component, a drug-containing inside layer covering the core, an intermediate layer which covers the inside layer and contains a cationic polymer soluble or swellable at a pH of 6.6 or below, and an outside layer which covers the intermediate layer and contains an anionic polymer soluble at a pH of 7.0 or above.

La présente invention concerne une préparation orale pharmaceutique présentant une excellente capacité à distribuer un médicament au gros intestin, plus spécifiquement une préparation orale pharmaceutique pour délivrer un médicament au gros intestin qui comprend un noyau contenant un agent de remplissage pharmaceutiquement acceptable en tant que composant essentiel, une couche intérieure contenant un médicament recouvrant le noyau, une couche intermédiaire qui recouvre la couche intérieure et contient un polymère cationique soluble ou pouvant gonfler à un pH inférieur ou égal à 6,6, et une couche extérieure qui recouvre la couche intermédiaire et contient un polymère anionique soluble à un pH supérieur ou égal à 7,0.

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