Oral preparations and process for production thereof

Details Oral preparations and process for production thereof Oral preparations and process for production thereof

A - Human Necessities

61

K

A61K 9/58 (2006.01) A61K 9/08 (2006.01) A61K 31/7048 (2006.01) A61K 47/04 (2006.01) A61K 47/32 (2006.01) A61K 47/34 (2006.01) A61K 47/38 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2569514

Oral preparations obtained by dispersing or dissolving a drug having an unpleasant taste and a high-molecular compound soluble in the stomach in a low- melting substance molten by heating to its melting point or above, granulating the obtained mixture, and coating the obtained composite granules with a coating composition comprising an insoluble high-molecular compound and a disintegrator at a weight ratio of 80 : 20 to 99 : 1; and a process for the production of the preparations. Oral preparations (such as fine granules) of the invention containing drugs having unpleasant tastes can keep the masking of the unpleasant tastes and the dissolution properties even under acid conditions.

Il est prévu des préparations orales obtenues par dispersion ou dissolution d~un médicament au goût désagréable et d~un composé fortement moléculaire soluble dans l~estomac dans une substance à faible point de fusion, fondue par chauffage à une température supérieure ou égale à son point de fusion, par granulation du mélange obtenu, et revêtement des granules composites obtenues à l~aide d~une composition d~enduction comprenant un composé fortement moléculaire insoluble et un désintégrateur à un rapport pondéral de 80:20 à 99:1; et un procédé de fabrication des préparations. Les préparations orales (comme de fins granulés) de l~invention contenant des médicaments au goût désagréable conservent leur capacité à masquer les goûts désagréables et leurs propriétés de dissolution même dans des conditions acides.

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