Oral rapid release pharmaceutical formulation for...

Details Oral rapid release pharmaceutical formulation for... Oral rapid release pharmaceutical formulation for...

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/4439 (2006.01)

Patent

CA 2648538

The invention relates to solid oral pharmaceutical compositions in the form of pellets, mini- tablets, tablets, or capsules, comprising an optionally substituted 2-(pyridylmethylsulfinyl)-1H- benzimidazole, for example esomeprazole, and carrageenan, and optionally one or more excipients. Surprisingly, it has been found that these compositions are stable and rapidly release the active ingredient. The pellets or mini-tablets may be coated as such, or filled in capsules or pressed into tablets, with a polymer, which dissolves only at a pH value of 5 or higher, optionally over a stabilizing intermediate layer.

L'invention concerne des compositions pharmaceutiques orales solides sous la forme de pastilles, mini-comprimés, comprimés ou capsules, comprenant un 2-(pyridylméthylsulfinyl)-1H-benzimidazole éventuellement substitué, par exemple l'ésoméprazole et le carraghénane, et éventuellement un ou plusieurs excipients. De façon surprenante, il a été découvert que ces compositions sont stables et libèrent rapidement le principe actif. Les pastilles ou les mini-comprimés peuvent être enrobés en tant que tels, introduits dans des capsules ou pressés en comprimés avec un polymère qui se dissout seulement à une valeur de pH de 5 ou au-dessus, facultativement sur une couche intermédiaire stabilisante.

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