Oral recombinant lactobacilli vaccines

Details Oral recombinant lactobacilli vaccines Oral recombinant lactobacilli vaccines

A - Human Necessities

61

K

A61K 39/00 (2006.01) C12N 15/74 (2006.01)

Patent

CA 2383433

Recombinant or modified Lactobacillus bacteria are described for use in vaccines. The bacteria express a heterologous antigen either intracellularly or on the surface of the bacteria, and will elicit an immune response. The vaccines are suitable for oral administration. Preferred bacteria are of the species Lactobacillus plantarum, especially L. plantarum 256.

L'invention concerne l'utilisation de bactéries Lactobacillus recombinées ou modifiées dans des vaccins. Ces bactéries expriment un antigène hétérologue, soit de manière intracellulaire, soit à la surface de la bactérie, et provoquent ainsi une réponse immunitaire. Ces vaccins conviennent pour une administration par voie orale. Les bactéries préférées sont celles de l'espèce Lactobacillus plantarum, en particulier L. plantarum 256.

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