Oral self-emulsifying formulations of pyranone protease...

Details Oral self-emulsifying formulations of pyranone protease... Oral self-emulsifying formulations of pyranone protease...

A - Human Necessities

61

K

A61K 31/4433 (2006.01) A61K 9/107 (2006.01) A61K 9/48 (2006.01) A61K 31/366 (2006.01)

Patent

CA 2424596

A microemulsion of pyranone protease inhibitor compounds that is substantially free of alcohol and propylene glycol comprising a pyranone protease inhibitor, one or more pharmaceutically acceptable surfactants, and a polyethylene glycol solvent having a mean molecular weight of greater that 300 but lower than 600, and a lipophilic component comprising medium chain mono- and di-glycerides, and optionally a basic amine.

L'invention concerne une micro-émulsion de composés inhibiteurs de protéase du pyranone, sensiblement exempte d'alcool et de propylèneglycol, comprenant un inhibiteur de protéase du pyranone, un ou plusieurs tensio-actifs pharmaceutiquement acceptables, et un solvant polyéthylène glycol présentant un poids moléculaire moyen supérieur à 300 mais inférieur à 600, et un composant lipophile comprenant des mono et diglycérides à chaînes moyennes, et éventuellement, une amine basique.

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