A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/26 (2006.01) A61K 9/48 (2006.01) A61K 47/32 (2006.01) A61K 47/34 (2006.01) A61K 47/44 (2006.01)
Patent
CA 2472744
The present invention relates to an immediate release formulation with enhanced bio-availability comprising a solid homogeneous and thermostable solution of a poorly water-soluble biologically active substance, characterised in that said solid solution comprises: a) the active substance in an amount of between 10 and 50% of the total weight of the formulation, b) a non-ionic hydrophilic surfactant ingredient, which is in the liquid form between 15~ and 30~C, in an amount of between 20% and 70 % of the total weight of the formulation and c) a pharmaceutically acceptable organic polymer or mixture of polymers, which polymer or mixture of polymers is in a liquid form above 60~C and in a solid form below 30~C, in an amount of between 5% and 70% of the total weight of the formulation, and d) optionally comprises a disintegrating agent in an amount of between 1% and 10% of the total weight of the formulation. The invention further relates to active substances formulated into the above form and methods for producing the formulation.
L'invention concerne une formulation à libération immédiate présentant une biodisponibilité augmentée, qui comprend une solution solide homogène et thermostable d'une substance à faible hydrosolubilité, biologiquement active, caractérisée en ce que ladite solution solide comprend: a) ladite substance active en quantité comprise entre 10 et 50 % du poids total de la formulation; b) un tensioactif hydrophile non ionique sous forme liquide entre 15 DEG et 30 DEG C, en quantité comprise entre 20 et 70 % du poids total de ladite formulation; c) un polymère organique pharmaceutiquement acceptable ou un mélange de polymères sous forme liquide à plus de 60 DEG C et sous forme liquide à moins de 30 DEG C, en quantité comprise entre 5 et 70 % du poids total de ladite formulation; et d) éventuellement un agent de désintégration en quantité comprise entre 1 et 10 % du poids total de ladite formulation. L'invention concerne en outre des substances actives formulées précédemment ainsi que des procédés de production de ladite formulation.
Fetherstonhaugh & Co.
Solvay Pharmaceuticals B.v.
LandOfFree
Oral solid solution formulation of a poorly water-soluble... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Oral solid solution formulation of a poorly water-soluble..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oral solid solution formulation of a poorly water-soluble... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1941273