Oral sustained release acetaminophen formulation and process

Details Oral sustained release acetaminophen formulation and process Oral sustained release acetaminophen formulation and process

A - Human Necessities

61

K

167/269

A61K 9/22 (2006.01) A61K 9/20 (2006.01) A61K 9/24 (2006.01) A61K 31/16 (2006.01) A61K 31/165 (2006.01)

Patent

CA 1315202

ABSTRACT An acetaminophen-sustained release tablet or tablet layer is formed by making a wet granulation, using Povidone (PVP) in water or alcohol-water as the granulating fluid which is mixed with acetaminophen, hydroxyethyl cellulose, a wicking agent e.g. microcrystalline cellulose, then drying and milling the granulation and blending with dry powdered erosion promoter, e.g. pregelatinized starch, wicking agent, lubricant e.g. magnesium stearate and glidant e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a slow release of the acetaminophen.

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