Oral tolerance induction by collagen to prevent allograft...

A - Human Necessities – 61 – K

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A61K 38/39 (2006.01) A61K 39/00 (2006.01) A61P 37/06 (2006.01) A61K 38/11 (2006.01)

Patent

CA 2402489

The present invention relates to the use of collagen and MHC-like compounds to down regulate immune responses. Methods for administration of such compounds that induce immune tolerance are described. The invention is important in the context of allograft rejection, transplantation, graft rejection, pleural disease and immunotolerance.

La présente invention concerne l'utilisation de collagène et de composés de type CMH, pour faire diminuer des réponses immunitaires. Cette invention concerne également des procédés d'administration de composés de ce type, permettant d'induire la tolérance immunitaire. L'invention s'avère particulièrement utile en ce qui concerne le rejet d'allogreffes, la transplantation, le rejet de greffes, les maladies pleurales, et l'immunotélorance.

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