Oral transmucosal delivery of drugs or any other ingredients...

A - Human Necessities – 61 – F

Patent

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Details

A61F 13/00 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 47/30 (2006.01)

Patent

CA 2333156

A device and method for the oral transmucosal delivery of active substances to the oral cavity utilizing an unplasticized polyvinyl pyrrolidone polymer (PVP) as the primary mucoadhesive. The device is applied and adheres to the mucosa of the oral cavity without causing side effects or leaving an unpleasant taste. Preferably the device is a bilayer tablet having a mucoadhesive layer and an overlying active substance containing layer. The mucoadhesive layer may contain PVP as the only adhesive or may be combined with other hydrophilic polymeric substances. The active layer also contains a hydrophilic polymer carrier. The layers in the device dissolve and release the active substance to the oral cavity and is particularly adapted for the delivery of substances active in the oral cavity such as breath fresheners and substances to combat dry mouth. It is also useful for the delivery of ionic drugs such as peptides.

L'invention concerne un appareil et un procédé permettant la distribution transmucosale orale de substances actives dans la cavité buccale, à l'aide d'un polymère de pyrrolidone polyvinylique (PVP) non plastifié tel qu'un mucoadhésif primaire. Ledit dispositif est appliqué sur la muqueuse de la cavité buccale, et y adhère sans provoquer d'effets secondaires et sans laisser de goût déplaisant. Le dispositif est, de préférence, un comprimé à deux couches possédant une couche mucoadhésive, et une couche contenant une substance active de revêtement. La couche mucoadhésive peut contenir un PVP comme adhésif unique, ou peut être associée à d'autres substances polymères hydrophiles. La couche active comprend également un excipient de polymère hydrophile. Ces couches se dissolvent dans le dispositif, et libèrent la substance active dans la cavité buccale. Elles sont particulièrement adaptées pour distribuer des substances actives dans la cavité buccale, telles que des produits purifiant l'haleine et des substances combattant le sécheresse de la bouche. Elles sont également utiles pour distribuer des médicaments ioniques tels que des peptides.

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